Shortcut's, the life is too short!

You're probably not a "keyboard geek" as MS is not exactly the best shorctutter. Now you can express youself and take advantage of the power of the keyboard's shorcuts. Here are just the most common ones

COMMAND + W = close window
COMMAND + Q = Quit application
COMMAND + S = save file
COMMAND + N = new window
COMMAND + T = new tab (in web browsers)
COMMAND + L = select address bar in browsers
COMMAND + SHIFT + N = create a new folder

Moreover, if it's still not enough, you can create combinatons of keys to create specific user-defined triggers by going into the "System preferences>Keyboard &Mouse>Keyboard shortcuts"
and then define some system-wide or application specific shortcuts (ex: COMMAND+F in quicktime to go in full screen if not already supported).

TIP: when creating shortcut just type in the exact menu item name and then the keys combination, and that's all:

int the field just type "Always on Top" and choose COMMAND+CTRL+T